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The fundamental framework for the ethical, humane and responsible care and use of animals for scientific purposes in Australia includes the application of the 3Rs – Replacement, Reduction and Refinement of animal use. This Information Paper provides information about the implementation of the 3Rs in Australia. For further information, please refer to the webpage about the 3Rs.

The Patient Blood Management Guidelines (the Guidelines) were developed following increasing evidence of transfusion-related adverse outcomes, leading to the emergence of new practices, including restrictive transfusion strategies and the increased use of alternatives to transfusion in the management of anaemia. 

This section includes examples of relevant international initiatives and activities, as well as general resources for specific topics.

This video is to provide Investigator Grants peer reviewers with some tips and tricks for peer review.

Hepatitis A is a liver disease caused by the hepatitis A virus, which is very infectious. Symptoms can include fever, tiredness, stomach pain, loss of appetite and nausea. This is sometimes followed by dark urine and yellowing of the skin and eyes (jaundice). Symptoms can last from 1 week to several months. Children under 3 years old rarely have any symptoms. Hepatitis A vaccine is recommended for people at higher risk of being infected.

Meningococcal infection is a severe but uncommon infection caused by a germ called Neisseria meningitidis, also known as meningococcus. There are several types of meningococcal bacteria that cause disease in humans. Most cases of meningococcal disease worldwide are caused by types A, B, C, W and Y. Vaccination against these types is available under the National Immunisation Program to give extra protection to people who are most at risk of meningococcal disease.Meningococcal infection can cause meningitis (infection of the membranes that cover the brain and spinal cord). The germ can also infect the blood, joints, eyes, lungs and skin. Symptoms in infants and young children include fever, refusing feeds, fretfulness, vomiting, a rash of reddish- purple spots or bruises, a high-pitched or moaning cry, and pale or blotchy skin. The child may be difficult to wake up.Meningococcal blood infections (septicaemia) can cause shock and death within hours ofsymptoms starting. In Australia, 5–10% of people infected with meningococcus die, even if they are treated promptly. Meningococcal disease can affect anyone; however, those at higher risk include infants, small children, adolescents and young adults.

Guideline impact Determining what measures to use are important, but equally important is to know how to use the data to tell a story.

Shigella is a germ that can cause a severe bowel infection. It is a type of gastroenteritis (or ‘gastro’). Symptoms include diarrhoea (sometimes containing blood or mucus), fever, vomiting and stomach cramps. Some infected people have no symptoms. Even very small numbers of the germs can cause an infection, so strict control measures are needed to stop it spreading.

Giardiasis is a form of gastroenteritis (or 'gastro') caused by a parasite called Giardia lamblia or Giardia duodenalis. This parasite can live in the bowels of people or animals. Untreated water that comes directly from lakes and rivers may also contain Giardia.Symptoms include diarrhoea, foul-smelling faeces (poo), cramping, gas, fatigue, nausea, and sometimes vomiting and weight loss. Fever and bloody faeces are not usually symptoms of Giardia infections. Many infected people have no symptoms.In education and care services, children and staff who have had Giardia may no longer have any symptoms but may still be infected with the parasite. This means their faeces can still infect others. A person with active diarrhoea is more likely to spread the disease than one who does not have diarrhoea, but still has the parasite in their faeces.

Frequently asked questions on the consideration of sex, gender, variations of sex characteristics and sexual orientation (the Variables) in health and medical research are answered below.

A guide for peer reviewers when evaluating industry-relevant skills, experience and achievements in its assessment of applicants’ track records.

Norovirus is a common viral cause of gastroenteritis (or ‘gastro’). Vomiting is usually the main initial symptom, and there can be a lot of vomit. Other symptoms include diarrhoea, nausea, stomach cramps, fever, headache and muscle aches. Norovirus gastroenteritis can cause dehydration because of the large amount of fluid lost through vomiting and diarrhoea.Outbreaks are common because norovirus spreads very easily and it only takes a small number of virus particles to make someone sick. The disease is more common from late winter to early summer.People who have had norovirus before can be reinfected as new strains of the virus spread around the world every few years.

Salmonella is a bacteria that causes gastroenteritis (or ‘gastro’) and occasionally bloodstream infection. Symptoms include diarrhoea (sometimes with blood or mucus in the faeces), fever, stomach pain, nausea and vomiting. The severity of the symptoms depends on the number of germs swallowed, the person’s age and their general health.Specific types of Salmonella cause typhoid and paratyphoid fever (see separate fact sheet). These can be more severe abdominal and bloodstream infections, but are generally only reported in returned travellers from countries where typhoid is common.

RSV is a common virus affecting the lungs and breathing passages. RSV in children usually causes mild to moderate cold-like symptoms lasting from 8 to 15 days. Symptoms include fever, runny nose, coughing and wheezing.In young children and babies under 12 months old, RSV can cause a chest infection called bronchiolitis. Signs of bronchiolitis include wheezing and difficulty breathing. This may get worse over the first 3 to 4 days before starting to improve. Some children and adults (particularly the elderly) need hospital treatment for their RSV lung infection.

Professor Anna Ralph is a practicing medical specialist and leads the Global and Tropical Health division at Menzies School of Health Research in Darwin.