Depression is a leading cause of disability worldwide1 and a major mental health issue in Australia. NHMRC-funded mental health researchers at The Australian National University (ANU) developed MoodGYM, an interactive, automated, online program designed to prevent or reduce symptoms of depression. This evidence-based, self-help program has helped over one million people worldwide manage their mental health. 

A landscape format version of this case study is available as a PDF from the Downloads section below.


In any one year, one million Australians experience depression2, while one in seven Australians experience it in their lifetime.3 Although effective treatments and preventive interventions exist, only a minority of people access them, often because they are not available at a time, place or in the form that they are needed. In addition, many people are reluctant to seek help due to stigma and because they prefer to manage the condition themselves.

During the mid-1990s, Professors Helen Christensen and Kathleen Griffiths were becoming increasingly aware of these barriers to access through their work as authors of NHMRC’s 1997 Depression in Young People: Clinical practice guidelines and through Griffiths’ experience as Executive Editor of the Department of Health and Aged Care’s 1999 Mental Health Promotion and Prevention National Action Plan.

At a time when public access to the internet was growing rapidly, they wanted to ensure treatment and preventive interventions for depression were more accessible. They realised that an online automated self-help program could:

  • be accessible at any time of the day or night, regardless of the user’s geographical location
  • help users learn how to manage their own symptoms
  • be cost-effective, helping many people at once
  • provide assistance anonymously thereby reducing stigma as a barrier
  • be the subject of a systematic program of research.

Together with other staff at the Centre for Mental Health Research (CMHR) and ANU, they began work to develop and evaluate this program.

Grants and Investment


From 1975-2001, NHMRC provided a series of grants to the research unit that became the CMHR. 
NHMRC also provided support for the capability development of several CMHR and associated researchers, including Helen Christensen, Kathleen Griffiths, Anthony Jorm, Ian Hickie, Andrew MacKinnon and Alison Calear.

Collectively, these researchers received the following NHMRC funding: 

  • 16 Project Grants (PGs)
  • 14 Research Fellowships (RFs)
  • 5 Centres of Research Excellence (CREs)
  • 2 Targeted Calls for Research (TCRs)
  • 2 Investigator Grants (IGs)
  • 1 Program Grant
  • 1 Early Career Fellowship (ECF)
  • 1 Career Development Fellowship (CDF).  

MoodGYM funding 


  • ACT Department of Health and Community Care (DHCC): 2000 
  • Commonwealth Department of Health (DoH): 2003, 2004, 2007, 2008-2021
  • Australian Research Council (ARC) Linkage Project Grant: 2006.

Other funding

  • Australia: Vincent Fairfax Family Foundation (2005), Lifeline (2006), Our Wellness Foundation (2009), Beyond Blue (2011)
  • Britain: The Multiple Sclerosis Society (2007), Capita, UK (2010)
  • Germany: Allgemeine Ortskrankenkasse (2013)
  • Norway: Research Council of Norway (2007), Regional Health Authorities (2009).


Collaborative research was made possible by ANU’s development of an online interface that enabled researchers around the world to implement online trials and download data. The interface also enabled MoodGYM to be translated into other languages – Norwegian (University of Tromsø), Dutch (Molemann Mental Health), Chinese (Beijing Suicide Research and Prevention Centre), German (University of Leipzig) and Finnish (City of Joensuu).


  • Lifeline Australia
  • Brain & Mind Centre, The University of Sydney,
  • Central Sydney Division of General Practice. 


  • Canada: St Michael’s Hospital, Centre for Addiction and Mental Health 
  • Germany: University of Leipzig, University Medical Centre Hamburg-Eppendorf
  • Netherlands: Vrjie Universiteit, Molemann Mental Health
  • Norway: University of Tromsø
  • UK: Universities of Warwick, Oxford and Sheffield
  • USA: Harvard Medical School 

ANU also facilitated trials in the USA, UK and Canada.

MoodGYM is based on Cognitive Behavioural Therapy (CBT), a psychological therapy known to be effective for depression when delivered face-to-face. CBT is based on the concept that it is not events that are responsible for our feelings but rather our thoughts and responses to these events. By identifying and challenging unhelpful thoughts and modifying our behaviours it is possible to improve our mood. The multi-media MoodGYM program provides training in CBT using five modules, interactive exercises and automated user feedback.


In 2001, Christensen and Griffiths launched MoodGYM and in 2004 they established ANU’s e-mental health research and development group (e-hub). MoodGYM has been the subject of many research trials in a range of settings over the past two decades. Results from the first randomised controlled trial (RCT) published in 2004 showed: the program could reduce depressive symptoms;3 this positive effect was maintained over 12 months;4 the program was associated with a reduction in personal stigma;5 and that it was cost-effective relative to conventional treatment.6

Research in 30 high schools in urban and rural Australia found MoodGYM was effective in preventing anxiety in boys and girls and depression in boys.7 Other trials in Australia and overseas found:

  • decreased depression, anxiety and alcohol misuse and improved quality of life of Lifeline callers with depressive symptoms who used MoodGYM8,9 
  • a preventive effect of MoodGYM among depressed Norwegian university students10,11 
  • positive outcomes for the use of MoodGYM as an adjunct to general practice12
  • improved wellbeing among visitors to a UK national health portal.13

Translation activities included:

  • informing government about/promoting the development of e-mental health (EMH) policy 
  • engaging with potential providers to undertake real-world research
  • distributing promotional material to schools and GPs through media interviews and other channels
  • providing resources to GPs and others, partnering (until 2016) with the government-funded eMental Health in Practice (eMHPrac) initiative.

Health Outcomes and Impact

MoodGYM has provided an evidence-based, alternative model for the delivery of depression treatment and prevention services. DoH funded ANU to deliver MoodGYM as a free service to the Australian public (2008-2021). Between 2004 and 2010, MoodGYM won 8 awards for innovative service. 

  • Over 1.3 million users have registered with MoodGYM worldwide. 
  • Users range in age from adolescence up to 75 years and older, with 23% from rural or remote areas and two-thirds being women (depression is twice as common in women). 
  • Data collected have shown that spontaneous visitors who use the program demonstrate a significant reduction in depressive symptoms.

Impact on practice and service

  • In 2021, in Australia, 40% of MoodGYM users were referred to the program by a health professional.
  • A 2014 survey showed that two-thirds of allied health professionals and 56% of GPs surveyed were aware of MoodGYM.
  • A 2011 published study reported that MoodGYM was one of the 3 health websites recommended most frequently by psychiatrists. 
  • MoodGYM has been recommended or mentioned as an option in clinical practice guidelines (2011 Beyond Blue; 2015, 2020 RANZCP). 


In October 2016, two e-hub staff members established a spin-off company (ehub Health Pty Ltd) to deliver MoodGYM. ehub Health was acquired in 2021 by the Canadian telehealth company Dialogue Health Technologies.


1997   Research Unit (CMHR)
1997 Clinical Guidelines for Depression in Young People
2000 PG (Hickie), DHCC Grant
2001 RF (Jorm & Christensen), MoodGYM v1 launched, PG (Hickie)
2002 Program Grant (Jorm)
2003 DoH grant, Schools trial
2004 DoH grant, GP trial
2005  MoodGYM v2 trial
2005 PG (MacKinnon) & other funding, MoodGYM v2 trial
2006  RF (Jorm & Christensen), ARC & other funding
2007  CRE (Christensen), PG (Jorm), RF (Hickie), DoH Grant, other funding
2008 DoH Grant, PG & RF (Jorm), MoodGYM v3 trial
2009 PG & RF (Griffiths), other funding
2010 Other funding
2011 PG (Christensen), ECF (Calear), Beyond Blue Guidelines, other funding
2012 TCR (Jorm), CRE (Christensen)
2013 PG (Christensen), other funding, RF & CRE (Hickie)
2014  PG (Jorm & Hickie), RF (Jorm, Griffiths & Christensen)
2015 PG (Christensen), PG (Calear), TCR (Jorm)
2016 ehub Health Pty Ltd established
2017 PG (Jorm), CDF (Calear)
2018 CRE & PG (Christensen), RF (Hickie)
2019 CRE (Hickie), RF (Christensen)
2020  IG (Jorm & Calear) 
2021 ehub Health acquired by Dialogue Health Technologies


Prof Helen Christensen AO

Professor Helen Christensen was formerly a Director of CMHR (2005-2012). She is Scientia Professor of Mental Health at UNSW Sydney and Board Director of Black Dog Institute). She was the Director and Chief Scientist at the Black Dog Institute from 2011-2021. She is also an ANU Emeritus Professor and Public Policy Fellow, a former NHMRC John Cade Research Fellow, a Fellow of the Australian Academy of Social Sciences and an inaugural Fellow of the Australian Academy of Health and Medical Sciences. In 2019, she was made an Officer of the Order of Australia (AO) for distinguished service to medical research through the development of on-line mental health treatment programs. She has been an investigator on 11 MoodGYM trials.

Prof Kathleen Griffiths

ANU Emeritus Professor Kathy Griffiths was formerly a Director of CMHR (2012-2016). She was also the Founding Director of CMHR’s Consumer Research Unit which facilitated the active engagement and leadership of consumers in mental health research. 

An ANU Public Policy Fellow, her work is focused on improving the lives of people with mental health problems. Griffiths pioneered research, development and dissemination of internet interventions to prevent and manage mental disorders. To date, she has been an investigator on 17 MoodGYM trials.

Key ANU researchers

Professor Anthony Jorm was an investigator on the original RCT of MoodGYM. Formerly a Director of CMHR (2001-2004) he is now a University of Melbourne Emeritus Professor. 

Professor Andrew Mackinnon was involved in 5 trials of MoodGYM. Previously at CMHR, he is now Professorial Fellow at the Centre for Mental Health at the University of Melbourne.

Professor Richard O’Kearney was an investigator on 3 trials of MoodGYM in schools. He is currently based at the ANU Research School of Psychology.

Professor Alison Calear undertook a trial of MoodGYM in schools and is now a Professor at CMHR.

Dr Louise Farrer undertook a trial of MoodGYM with Lifeline and is now a Research Fellow at CMHR.  

Dr Kylie Bennett studied community users of MoodGYM and has been an investigator on 6 MoodGYM trials. Bennett is the Managing Director of ehub Health. 

Dr Ben Healey led and published an RCT on MoodGYM as part of his undergraduate medical studies.

Other key researchers

Professor Ian Hickie, Co-Director, Health and Policy at The University of Sydney’s Brain and Mind Centre and currently an NHMRC Senior Principal Research Fellow, was an inaugural NHMRC Australia Fellow at the time he was an investigator on the trial of MoodGYM in general practice.  

Professor John Powell (UK) was Professor of Public Health at Warwick University and Clinical Director for the UK’s NHS Choices when he led a trial of MoodGYM on the NHS website. He is now Professor of Digital Health Care at Oxford University and Consultant Clinical Advisor at the National Institute for Health Care Excellence, UK.

Professors Martin Eisenmann, Knut Waterloo and Nils Kolstup from the University of Tromsø led trials of MoodGYM in Norway including among university students (ME, KW), school students (ME, KW) and general practice (NK). PhD students: Dr Ove Lintvedt (now a researcher at the University of Tromsø) initiated the Norwegian collaboration and undertook the first Norwegian RCT; Dr Ragnhild Høifødt (now an Associate Professor at the University of Tromsø) undertook a trial in general practice; and Associate Professor Kjersti Lillevoll undertook a trial in high schools.


This case study was developed in partnership with The Australian National University. 
The information and images from which impact case studies are produced may be obtained from a number of sources including our case study partner, NHMRC’s internal records and publicly available materials.


  1. World Health Organisation. 2022. Depression. [online].
  2. Australian Bureau of Statistics. National Survey of Mental Health and Wellbeing: Summary of Results, 2007. ABS; 2008. Available from:
  3. Christensen H, Griffiths KM, Jorm AF. Delivering depression interventions using the internet: randomised controlled trial. British Medical Journal. 2004;328(7434):265. (BlueMood RCT)
  4. Mackinnon A, Griffiths KM, Christensen H. Comparative randomised trial of online cognitive-behavioural therapy and an information website for depression: 12-month outcomes. British Journal of Psychiatry. 2008; 192(2), 130-134. (BlueMood RCT)
  5. Griffiths KM, Christensen H, Jorm AF, Evans K, Groves C. Effect of web-based depression literacy and cognitive-behavioural therapy interventions on stigmatising attitudes to depression: Randomised controlled trial. British Journal of Psychiatry. 2004;185(4):3429. (BlueMood RCT)
  6. Christensen H, Griffiths KM. Reaching standards for dissemination. MedInfo 2007. (Eds K. Kuhn et al.): IOS Press, pp 459-463. (BlueMood RCT – cost effectiveness study)
  7. Calear AL, Christensen H, Mackinnon A, Griffiths KM, O'Kearney R. The YouthMood project: A cluster randomized controlled trial of an online cognitive-behavioral program with adolescents. Journal of Consulting and Clinical Psychology. 2009;77(6):1021-1032. (YouthMood clustered RCT)
  8. Farrer L, Christensen H, Griffiths KM, Mackinnon A. Internet-based CBT for depression with and without telephone tracking in a national helpline: Randomised controlled trial. PLOS One. 2011; 6(11):e28099. (Lifeline ECCO RCT)
  9. Farrer L, Christensen H, Griffiths KM, Mackinnon A. Web-based cognitive behavior therapy for depression with and without telephone tracking in a national helpline: Secondary outcomes from a randomized controlled trial. Journal of Medical Internet Research. 2012;14(3): 64-73. (Lifeline ECCO RCT)
  10. Lintvedt OK, Griffiths KM, Sørensen K, Østvik AR, Wang CEA, Eisemann M et al. Evaluating the effectiveness and efficacy of unguided internet-based self-help intervention for the prevention of depression: a randomized controlled trial. Clinical Psychology & Psychotherapy. 2013;20(1):10-27. (Norwegian RCT)
  11. Lintvedt OK, Griffiths KM, Eisemann M, Waterloo K. Evaluating the translation process of an internet-based self-help intervention for prevention of depression: a cost-effectiveness analysis. Journal of Medical Internet Research. 2013; 15(1):e18. (Lifeline ECCO RCT) (Norwegian RCT)
  12. Hickie IB, Davenport TA, Luscombe GM, Moore M, Griffiths KM, Christensen H. Practitioner-supported delivery of internet-based cognitive behaviour therapy: evaluation of the feasibility of conducting a cluster randomised trial. Medical Journal of Australia. 2010;192(11 Suppl):S31-5. (GP clustered RCT)
  13. Powell J, Hamborg T, Stallard N, Burls A, McSorley J, Bennett K, et al. Effectiveness of a web-based cognitive-behavioral tool to improve mental well-being in the general population: randomized controlled trial. Journal of Medical Internet Research. 2013;15(1):e2. (UK National Health Service RCT)

Other research

Healey BJ, Griffiths KM, Bennett K. The effect of programme testimonials on registrations for an online cognitive behaviour therapy intervention: a randomised trial. Digital Health. 2017;3,2055207617729937. (RCT)

Yeung A, Wang F, Feng F, Zhang J, Cooper A, Hong L, et al. Outcomes of an online computerized cognitive behavioral treatment program for treating Chinese patients with depression: A pilot study. Asian Journal of Psychiatry. 2018;38:102-7. (RCT China (completers))


List of NHMRC Grants

Professor Helen Christensen

  • Research Fellowship (RF): 2001, 2006, 2009 2014, 2019
  • Project Grant (PG): 2009, 2011, 2013, 2014, 2015, 2018
  • Centre of Research Excellence (CRE): 2007, 2012, 2018

Professor Kathleen Griffiths

  • RF: 2009, 2014
  • PG: 2008

Professor Anthony Jorm

  • RF: 2001, 2006, 2009, 2014
  • Program Grant: 2002
  • PG: 2007, 2008, 2014, 2017
  • Targeted Call for Research (TCR): 2012, 2015
  • Investigator Grant (IG): 2020

Professor Ian Hickie

  • PG: 2000, 2001, 2014
  • RF: 2007, 2013, 2018
  • CRE: 2013, 2019

Professor Alison Calear

  • Early Career Fellowship (ECF): 2011 
  • PG: 2015
  • Career Development Fellowship (CDF): 2017
  • IG: 2020

Professor Andrew MacKinnon

  • PG: 2005


File type
0.46 MB
pdf / 0.46 MB Download