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In Australia, approximately 1.2 million people are affected by an immune-system disease. For a majority of these diseases, women are three times more likely to be afflicted than are men. As a group, immune-system diseases are the third leading cause of morbidity and mortality in the industrialised world, surpassed only by cancer and heart diseases.
The purpose of this statement is to clarify the expectations of the National Health and Medical Research Council (NHMRC) with respect to the use of the forced swim test in rodents in NHMRC-funded research. It can also be used by those involved with, or considering, the use of the forced swim test in rodents in research funded from other sources.