Research Excellence: Pioneering Early Cancer Detection through Nanotechnology
Dr Jiayan Liao is a dedicated researcher specialising in the field of nanotechnology, nanomedicine, biomedical engineering, and their applications in medical diagnostics. Dr Liao’s research focuses on developing innovative diagnostic tools for early cancer detection, leveraging photonics, fluorescent nanoprobes, and artificial intelligence for precise detection of single-molecule biomarkers in diseases and cancers. Dr Liao is contributing to the advancement of diagnostic methodologies and technologies, aiming for non-invasive, early detection methods to improve patient outcomes.
Research Excellence: Solving Australia's Hypertension Treatment Problem
Professor Alta Schutte, SHARP Professor and Principal Theme Lead of Cardiac, Vascular and Metabolic Medicine at the University of New South Wales and The George Institute for Global Health, focuses on implementing effective scalable interventions for global blood pressure control. Appointed Co-Chair of the National Hypertension Taskforce in 2022, she was recognised in 2023 as the Leading Researcher in Vascular Medicine by The Australian. Notably, she received the 2022 Harriet Dustan Award from the American Heart Association and the 2023 Peter Sleight Excellence award from the World Hypertension League. Her impactful work extends to improving cardiovascular health in Australia and beyond.
Speaking of Science: Towards a National Indigenous Genomics Agenda
Harnessing the power of research by combining genomics, precision medicine and public heath can help to address the long-term health and wellbeing of Aboriginal and Torres Strait Islander people.
Research Excellence: Designing adaptive strategies to drive tuberculosis towards elimination
Dr Romain Ragonnet is a Senior Research Fellow in the Epidemiological Modelling Unit at Monash University. Dr Ragonnet specialises in the mathematical modelling of tuberculosis (TB) and COVID-19, and his notable contributions include the first-ever quantification of TB mortality and self-recovery rates. Dr Ragonnet has advised various governments of lower-middle-income countries in the Asia-Pacific region to assist the local control of TB and COVID-19. He also initiated and led multiple cross-disciplinary collaborations, creating a strong network of world-leading experts that spans mathematics, medical ethics, biostatistics, economics, and clinical trials.
Research Excellence: Unlocking molecular vulnerabilities in childhood brain cancers
Dr Sean Humphrey leads the Functional Phosphoproteomics Laboratory at the Murdoch Children’s Research Institute. Dr Humphrey’s research uses cutting-edge mass spectrometers to create detailed molecular maps that capture how cells communicate and process information by regulating proteins. Dr Humphrey completed his PhD at the University of New South Wales before moving to Germany to undertake post-doctoral training at the Max Planck Institute of Biochemistry in Munich. Dr Humphrey’s research pinpoints key molecular signals that are dysregulated in human disease, uncovering a myriad of new targets for future therapies.
Research Excellence: Epidemiology and equity of kidney failure in Australasia
Dr Johanna Birrell is a general physician and advanced trainee in public health medicine. Dr Birrell has trained in both Australia and New Zealand and has a particular interest in rural health, Indigenous health, and health services research. Dr Birrell is completing her postdoctoral studies at the University of Sydney with concurrent clinical work. Her research explores geographic variation in kidney failure epidemiology and access to care across Australia and New Zealand. Dr Birrell has received awards including the Royal Australasian College of Physicians 2023 Aotearoa Trainee Research Award for Excellence in the Field of Adult Medicine and the Gerry Murphy Prize in 2022.
Speaking of Science: International Women’s Day 2024 - Inspire Inclusion
International Women’s Day represents a day of collective global activism and celebration that belongs to all of those committed to forging women’s equality.
In this Speaking of Science webinar held for International Women’s Day, we were joined by members of NHMRC’s Research Committee to discuss this year’s theme of ‘Inspire Inclusion’.
Speaking of Science: Ovarian Cancer Awareness Month- Early detection, risk prediction and improving prognosis
Around 1,786 new cases of ovarian cancer in Australia were estimated to have been diagnosed in 2023, which is the equivalent of a 1 in 87 lifetime risk.
In our first Speaking of Science webinar, held for Ovarian Cancer Awareness Month, we were joined by international expert in ovarian cancer research, Professor Susan Ramus (Professor of Molecular Oncology in the School of Clinical Medicine at the University of New South Wales).
Growing up and getting stronger: improving the long-term health of premature babies
In the early 1970s, Professor Lex Doyle watched as ventilators were introduced in Australian hospitals to help premature babies breathe.
Accelerating change in driver safety screening
While many older Australians value the independence of driving and continue to do so safely throughout their lives, for others, the changes that occur with aging may take them off the road.
Harnessing the power of natural immunity to extend vaccine protection
Associate Professor Linda Wakim is focused on using our body’s own immune defence system to improve vaccines by providing longer lasting protection against viruses.
Community-designed and delivered suicide intervention
Warning: Some people may find parts of this content confronting. If this material raises any distress, contact Lifeline on 13 11 14, Call 13YARN or Kids Helpline on 1800 55 1800.
A self-described grassroots Aboriginal researcher, Professor Maree Toombs is responsible for developing the first Indigenous-led and designed suicide intervention training program in Australia, creating space for connection to traditional lands and culture as part of life-saving support.
Fighting biofilms with a Trojan Horse
Dr Nicky Thomas started his career as a pharmacist. During his PhD, he was investigating how encasing medicine in lipid droplets could improve its efficacy when he was asked: can this lipid technology be used to treat biofilms?
Improving fertility treatment through innovation
Professor Robert Gilchrist is a part of a bench-to-bedside research success story, innovating existing infertility treatments to offer a less invasive and cheaper alternative to in-vitro fertilisation (IVF).
Mentors inspire an Indigenous research career with impact
Professor Cath Chamberlain, a Palawa woman of the Trawlwoolway clan (Tasmania), received an NHMRC Early Career Fellowship in 2014 to find culturally safe ways to improve cardiometabolic health outcomes in Aboriginal and Torres Strait Islander mothers.
Driving change in aged care pharmacy practices through data
Having practised as a hospital pharmacist by day and a residential aged care pharmacist by night, Dr Lisa Pont naturally began to think about how pharmacists could work differently as part of her research.
Enhancing future pain treatments using venoms
Professor Richard Lewis and his team from the Institute of Molecular Bioscience at University of Queensland made a notable discovery early in their research after a lab assistant observed one could milk cone snails for venom much more quickly if you gave them 'a poke or two'.
Delivering a legacy of culturally safe maternity care
Professor Rhonda Marriott AM, a descendant of Nyikina people of the Kimberley, has devoted five decades to nursing and midwifery in clinical, academic and research roles.
Research Excellence: Supporting healing and recovery for Aboriginal and Torres Strait Islander survivors of childhood sexual abuse
Dr Graham Gee is an Aboriginal-Chinese man, also with Celtic heritage, originally from Darwin. His Aboriginal-Chinese grandfather was born near Belyuen on Larrakia Country. Dr Gee is a clinical psychologist and has worked at the Victorian Aboriginal Health Service for 11 years before taking up a research position at the Murdoch Children’s Research Institute. His early career research focused on Aboriginal and Torres Strait Islander mental health, social and emotional wellbeing, resilience and complex trauma. In 2022, Dr Gee commenced working in partnership with several Victorian Aboriginal services dedicated to healing child sexual abuse. Read more to find out more about Dr Gee’s research, in his own words.
Research Excellence: Microelectrode recordings from the vagus nerve in awake humans
Professor Vaughan Macefield is the Professor of Neuroscience in the Department of Neuroscience at Monash University. Professor Macefield specialises in recording from single nerve fibres via microelectrodes inserted into the peripheral nerves of awake human participants. He is best known for developing the methodology for recording the firing properties of single, type-identified, sympathetic neurones supplying muscle and skin, and for developing the methodology for recording muscle sympathetic nerve activity at the same time as performing functional magnetic resonance imaging of the brain. Read on to find out more about Professor Macefield's research, in his own words.
Tackling health challenges of the present and the future
As an infectious disease physician and researcher in HIV, vaccine development and the impact of the microbiome on human health, Professor Wesselingh brings a wealth of medical experience, clinical leadership as well as national and international success to this role.
Research Excellence: Understanding membrane protein structures
Dr Alastair Stewart, Head of the Institute’s Structural Biology Laboratory at the Victor Chang Cardiac Research Institute (VCCRI) focuses his research on understanding the mechanisms of how cells transport drug molecules using cyro-electron microscopy technology. Based within VCCRI’s Innovation Centre, Dr Stewart’s research involves generating detailed information on the function of membrane protein structures, providing a template to better understand drug interactions within the body. Read on to find out more about Dr Stewart’s research, in his own words.
Research Excellence: trialling women's testosterone therapy
Professor Susan Davis AO, Head of the Monash University Women’s Health Research Program, focuses her research on understanding the role of sex hormones, particularly testosterone, in women’s health. Her program of research involves a series of innovative, complementary clinical trials to determine if the hormone can serve as a new therapy to protect against leading causes of ill health in postmenopausal women. Read on to find out more about Professor Davis’s research, in her own words.
Research Excellence: predicting gastric cancer
Dr Doug Tjandra is an advanced trainee in gastroenterology at The Royal Melbourne Hospital with an interest in preventing gastrointestinal cancers and immunotherapy-related complications of the gastrointestinal tract and liver.
Research excellence: understanding the first few weeks of pregnancy
Professor Jose Polo’s work in epigenetics spans diverse fields, including cellular reprogramming, embryogenesis, neurobiology, immunology and cancer. His Synergy Grant brings together a multidisciplinary team who will combine the latest advances in models of early development, genetics and molecular biology to determine how the early placenta produced by the embryo burrows into the uterus and keeps developing during the entire pregnancy.
Research Excellence: rapidly detecting emerging viruses
It is challenging to contemplate, but the world can expect to experience pandemics like COVID-19, and perhaps even larger in scale, in the future. Professor Eddie Holmes is developing a pandemic radar to rapidly detect emerging viruses and determine which are most likely to have pandemic potential. His research focuses on understanding the fundamental mechanisms of virus ecology and evolution, as well as how viruses jump species boundaries to emerge and cause disease in new hosts.
Excellence in ethics and integrity
Reverend Kevin McGovern, recipient of the 2023 NHMRC Ethics and Integrity Award, is one of Australia’s leading ethicists, active in education, research and policy for over 25 years. Throughout his professional life as a parish priest, academic and community leader, Reverend McGovern has brought to innumerable discussions and debates the highest quality and intensity of consideration. His reputation for the courage of his convictions and his openness and respect for others with a diversity of views is unparalleled.
Excellence in consumer engagement: optimising the lives of people with aphasia
The Queensland Aphasia Research Centre (QARC) brings together people with aphasia, their families and friends, clinicians and researchers in the collaborative development of innovative and novel health interventions that transform lives. At NHMRC's Research Excellence Awards in March, QARC received the 2023 NHMRC Consumer Engagement Award, which recognises an individual, a group of individuals or an organisation that has made a long-term contribution to consumer and community involvement in health and medical research.
Research Excellence: A vision for the elimination of tuberculosis
Professor Greg Fox is a respiratory doctor and clinical trialist at the University of Sydney and Director of the Sydney Vietnam Institute who is contributing to the momentum towards tuberculosis (TB) elimination. Professor Fox received the 2021 NHMRC David Cooper Clinical Trials and Cohort Studies Award, recognising the highest ranked recipient in the Clinical Trials and Cohort Studies scheme.
Research excellence: Transforming midwifery in the Asia-Pacific region
Professor Caroline Homer AO is a midwife and maternal and newborn health researcher. Her research addresses maternal and newborn health issues, especially the role of midwives in improving outcomes in limited-resource settings, with a focus for more than 20 years on the Asia-Pacific region.
Research Excellence: New antibody therapies against malaria and COVID-19
Professor Wai-Hong Tham was one of four distinguished female researchers to receive 2022 NHMRC Elizabeth Blackburn Investigator Grant Awards. Her award was for the highest ranked female recipient (Leadership category) in the Basic Science research area of the Investigator Grants scheme. Professor Tham is Head of the division of Infectious Diseases and Immune Defence at WEHI and co-Chair of the WEHI Biologics Initiative.
Research Excellence: Identifying gaps and solutions needed for HIV elimination
Dr Tafi Marukutira is a medical doctor and public health researcher, specialising in infectious diseases epidemiology. Dr Marukutira received the 2022 NHMRC Frank Fenner Investigator Grant Award (Emerging Leadership), which recognises the highest ranked recipient in the Emerging Leadership Level 1 Investigator Grant category within the Basic Science or Public Health research areas, for his work on equitable access to HIV care and treatment.
Communities driving health care research
'It’s about coming with an open mind and heart, and willingness to deeply listen to community… to have any preconceptions challenged and re-learn ways of doing research' - Dr Veronica Matthews , co-lead investigator, STRengthening systems for InDigenous healthcare Equity (STRIDE)
Forging a farsighted agenda with a novel global way of thinking about science
The Human Frontier Science Program (HFSP) was established in 1990 to promote international collaboration in basic research focused on the elucidation of the sophisticated and complex mechanisms of living organisms. Since then, 1180 research grants have been awarded to more than 7500 researchers representing 71 nationalities, including Australia.
HFSP Secretary-General Professor Pavel Kabat introduces the program and three prominent researchers tell us how their HFSP grants advanced their research.
A paradigm shift in kidney research
Surprisingly, understanding of organ assembly is extremely limited. Professor Melissa Little and team received an Human Frontier Science Program (HFSP) grant and established the most comprehensive quantitative image-based analysis of any organ ever described. The challenges of bringing together researchers from different fields is one of vocabulary, but the benefit is considerable.
Towards cyborg biology - electrochemical biosensors of everything
There is a long running interest in the idea of machine-organism hybrids, although the integration of electronic and biological systems remains underdeveloped. Professor Kirill Alexandrov and his collaborators received Human Frontier Science Program (HFSP) funding to explore the 'undoable'. Multidisciplinary teams are a must and spur new creative projects.
Lipid droplets and our defensive arsenal - killing the bacteria to prevent infection
Lipid droplets are exploited by pathogens that invade cells and then use the cellular lipid droplets as a source of fats. Professor Rob Parton and his team received a Human Frontier Science Program (HFSP) grant to explore the possibility that lipid droplets might also be a crucial form of defence against pathogens. International collaborative networks have allowed access to techniques and expertise. They have also facilitated mentoring and collaboration for students and early career researchers.
Making a decision to do the hard research, that’s what discovery is about
Deciding to commit to a research life is brave – so is committing to do the hard research. Professor Cath Chamberlain says with Aboriginal and Torres Strait Islander health, in particular, 'we are going to need to take some more risks to do things differently'.
Internship brings entirely new set of skills
Sharna Motlap has always been interested in creating and implementing evidence-based programs specifically tailored to Indigenous communities.
Regional research collaborations fighting dengue fever
The spread of Japanese encephalitis virus in south eastern Australia is a reminder that mosquito-borne viruses pose an ongoing threat to lives and livelihoods, particularly in our region. That includes dengue fever spread by the Aedes aegypti mosquito. Australian researchers are collaborating closely with colleagues on two fronts – to eradicate the virus and find biomarkers that will lead to better diagnosis and treatment.
A passion project to make the heart sing: Urban planning for healthier lives
Professor Billie Giles-Corti was a 'lone wolf', she says, when she started her research career. In 2022, the time has come for public discourse about the direct links between city planning and health. She is part of a global network making the connections between liveability and health outcomes.
HEAL national research network addressing the health effects of environmental change
The Healthy Environments and Lives National Research Network (HEAL) was announced at the end of 2021 with a grant of $10 million over five years, as an NHMRC Special Initiative to provide national and international leadership in environmental change and health research. HEAL formally starts in May 2022; a lot of groundwork has been done to create the foundations for a large and diverse collaboration to deliver its ambitious work plan over the next five years and beyond.
Speech is a uniquely human skill many take for granted
Professor Angela Morgan is head of speech and language at the Murdoch Children’s Research Institute and Professor of Speech Pathology at the University of Melbourne and was the recipient of the 2020 NHMRC Elizabeth Blackburn Investigator Grant Award (Leadership in Clinical Medicine and Science).
To improve child health, focus on conception
Professor Sarah Robertson from The University of Adelaide is recipient of an NHMRC Investigator Award and was awarded the Elizabeth Blackburn Investigator Grant Award (Leadership in Basic Science) at the 2020 NHMRC Research Excellence Awards.
How Anne McKenzie went from ‘just a mum from Morley’ to consumer engagement champion
Pioneering health consumer advocate Anne McKenzie AM has been awarded NHMRC’s Consumer Engagement Award in recognition of an almost 30-year career during which she has helped thousands of Australian clinicians and researchers understand the value of listening to consumers.
Developing innovative vaccines to tackle influenza B virus
Dr Marios Koutsakos is a postdoctoral research fellow at the Peter Doherty Institute for Infection and Immunity, University of Melbourne. He works on the development of a universal influenza B vaccine and on understanding the fundamental biology of immune responses to vaccination. Dr Koutsakos received the 2020 NHMRC Frank Fenner Investigator Grant Award.
Developing innovative interventions to eliminate parasitic worm infestations
Professor Don McManus is senior scientist at QIMR Berghofer and an internationally acclaimed parasitologist. This year, he was awarded the 2020 NHMRC Peter Doherty Investigator Grant Award (Leadership).
Patient collaborators in groundbreaking brain cancer research
Patients are collaborators along with structural biologists, immunologists and neurosurgeons in the groundbreaking brain cancer research being conducted by the tight, multidisciplinary team being led by WEHI’s Associate Professor Misty Jenkins.
Science to art: Research behind the science behind the image
Professor Frédéric (Fred) Hollande is Deputy Head at the Department of Clinical Pathology, University of Melbourne, and a group leader at the University of Melbourne Centre for Cancer Research. He’s also behind the image recognised in the Science to Art NHMRC Biennial Award.
Game-changer for cancer research and therapeutic development
2021 ANSTO Eureka Prize for Innovative Use of Technology