NHMRC opened a Targeted Call for Research (TCR) into Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) on 23 October 2019. Applications closed on 29 January 2020.

The development of this TCR was guided by the Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) Advisory Committee established by the NHMRC.

The intended aims of this TCR were to:

  • Develop a scientifically valid, evidence-based understanding of the pathophysiology and aetiology of ME/CFS and the way it impacts on the physical, social and psychological wellbeing of affected persons.
  • Identify approaches that will assist patients presenting with symptoms of ME/CFS to be accurately diagnosed, including the identification potential biomarkers to facilitate effective management and treatment.
  • Cultivate interdisciplinary research collaboration, both locally and internationally.

Applications received during the call were peer reviewed by an expert panel. Following peer review, three applications were funded by NHMRC. Details of the awarded grants are provided in the table below. Annual progress reports can be found on the reports page.

App ID Chief Investigator A Application Title Administering Institution Budget Grant duration
APP1199363 Professor Ken Walder Using ‘omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS  Deakin University $1,083,010.00 2020-2025 
APP1199502 Professor Sonya Marshall-Gradisnik Ion channel dysfunction in the pathophysiology of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: diagnostic biomarkers, therapeutic targets and treatments Griffith University $1,460,700.00 2021-2025
APP1200292 Professor Paul Gooley Exploring the role of nitrogen metabolism, energy metabolism and mitochondrial function in the pathophysiological mechanisms of paediatric ME/CFS University of Melbourne $784,063.50 2020-2023