- the application of high standards of scientific integrity
- the application of Replacement, Reduction and Refinement (the 3Rs) at all stages of animal care and use. (Clause 1.1 [iv] and [v])
Issues that affect the reproducibility of research involving animals, and may result in the potential wastage of animals used and the unnecessary use of animals, include:
- the quality of methodologies used in animal-based research
- poor reporting of key information on how the animal studies are designed, conducted and analysed.
NHMRC’s Animal Welfare Committee is developing advice for institutions, investigators and animal ethics committees to highlight these issues and provide practical strategies on how to address them. The draft Best practice methodology in research involving animals is currently undergoing targeted consultation.