Resources for guideline developers

Methods for rating the quality of evidence

NHMRC uses GRADE (Grading of Recommendations, Assessment, Development and Evaluation) in the development of its guidelines. GRADE is an internationally recognised approach to rate the quality of evidence and the strength of recommendations and is considered to be the standard in guideline development.

Guidelines developers seeking NHMRC approval of their guidelines may use either GRADE or the earlier NHMRC levels of evidence and grades for recommendations for developers of guidelines (2009) for rating the quality of evidence.  These options are documented in the Procedures and requirements for meeting the 2011 NHMRC standard for clinical practice guidelines.

It should be noted that NHMRC has no plans to update or maintain the NHMRC levels of evidence and grades for recommendations for developers of clinical practice guidelines (2009)

A guide to the development, evaluation and implementation of clinical practice guidelines and accompanying handbooks

The NHMRC is currently working with an expert advisory committee to develop a new handbook for guideline developers that will supersede NHMRC’s current suite of methodological advice.

This handbook will be made available as an online resource, and provide current practical advice on guideline development in order to meet the 2016 NHMRC Standard for Guidelines.

The advice will be developed and published in self-contained modules on the NHMRC website which can be easily updateable as new evidence becomes available. The modules will cover a range of topics such as guideline implementation, conflicts of interest and scoping complex guidelines for public health or environmental issues. NHMRC is hoping to release the first tranche of modules in 2017.

To be notified of any consultation processes or to find out more information please contact the clinical guidelines team via

Information documents and templates to assist guideline developers seeking NHMRC approval

Information on the NHMRC procedures and requirements to meet the 2011 NHMRC standard for clinical practice guidelines

Guideline development and conflicts of interest

For further assistance please contact the NHMRC clinical guidelines team via email or call 02 6217 9100.