NHMRC Guidelines for Monoclonal Antibody Production

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Note: This publication was revoked by NHMRC in 2017. The use of animals for monoclonal antibody production, especially the use of the ascites method in mice, was a significant issue at the time of publication. The guidance in this publication is no longer relevant because of the existence of viable non-animal alternatives for monoclonal antibody production.

NHMRC has made this publication available on its internet archives site as a service to the public for information purposes only.


These guidelines have been developed by NHMRC on advice from its Animal Welfare Committee in response to the growing need for further emphasis on the principles of Replacement and Refinement as they apply to the use of animals for the production of monoclonal antibodies. These guidelines also assist institutional Animal Ethics Committees in the evaluation of applications involving monoclonal antibody production.

This document should be read in conjunction with the Australian Code for the Care and Use of Animals for Scientific Purposes 8th edition (2013).