Research into Debilitating Symptom Complexes Attributed to Ticks

The Australian Government recognises the need for research into debilitating conditions attributed to ticks, including Lyme-like illnesses. 

In April 2017, the Minister for Health, the Hon Greg Hunt MP, asked the NHMRC’s CEO to fast-track a Targeted Call for Research (TCR) into Lyme-like illnesses in Australia, with funding of up to $3 million.  A TCR is a one-time solicitation for grant applications to address a specific health issue.  NHMRC anticipates that a TCR on this subject will be held in 2018.

The Australian Government, through the Department of Health, has proposed alternative nomenclature to describe the heterogeneous nature of the debilitating symptom subgroups with acknowledgement that ticks may have a role – “Debilitating Symptom Complexes Attributed to Ticks”.

Advisory Committee for Research into Debilitating Symptom Complexes Attributed to Ticks

NHMRC has established the Advisory Committee for Research into Debilitating Symptom Complexes Attributed to Ticks to assist with the background work required in setting up the TCR before NHMRC can call for applications. In particular, the Advisory Committee will help to define the research question of the TCR in a way that will make the best use of the available funds.  It will help to pinpoint what research will be in scope of the TCR and provide contextual information on the background, aims and desired outcomes of the TCR. 

Membership

The Advisory Group includes a range of scientific experts, including infectious disease physicians, and a consumer representative.

Dr Ann Koehler (Chair)

Director
Communicable Disease Control Branch
Public Health & Clinical Systems
Department for Health and Ageing
Government of South Australia

Reverend Doctor Nikki Coleman Patient representative on the Chief Medical Officer of Australia's Clinical Advisory Committee on Lyme Disease and Visiting Research Fellow, Yale University Interdisciplinary Center for Bioethics
Associate Professor Josh Davis Infectious Diseases physician in Newcastle; Principal research fellow at Menzies School of Health Research
Professor Lindsay Grayson Director, Department of Infectious Diseases & Microbiology, Austin Health; Director, Hand Hygiene Australia; Professor, Department of Medicine, University of Melbourne
Professor Ben Howden

Director, Microbiological Diagnostic Unit Public Health Laboratory and
Medical Director, Doherty Applied Microbial Genomics,
The University of Melbourne at The Doherty institute for Infection and Immunity

Professor Nigel Stocks Head of the Discipline of General Practice at the University of Adelaide

Note:

NHMRC has well defined procedures for the formation of advisory panels which are based on obtaining the best experts available while ensuring conflicts of interest (real and perceived) are managed appropriately.

NHMRC does not allow people to apply to a TCR if they have assisted with the development of the research question or associated policies of that TCR. This requirement has been taken into consideration when identifying potential Advisory Committee members.

The Advisory Committee will not review the research applications that will be submitted to the TCR.  That role will be performed by a separate peer review committee of scientific experts.  However, members of the Advisory Committee may be invited to participate in the peer review assessment process for the TCR, if required at the time.

Progress Update

(This section will be updated regularly following Advisory Committee meetings and as otherwise appropriate)

The first meeting of the Advisory Committee was held on 1 August 2017.

The Advisory Committee is considering the following information as part of its deliberations:

The next meeting is expected to be held in October/November 2017.

Terms of Reference

Under the National Health and Medical Research Council (NHMRC) Act 1992, the Advisory Committee for Debilitating Symptom Complexes Attributed to Ticks, reporting to NHMRC’s Chief Executive Officer, will:

  1. Identify unmet need or significant research knowledge gaps and emerging issues in Debilitating Symptom Complexes Attributed to Ticks research, both in Australia and internationally.
  2. Contribute to development of a specifically defined targeted call for research based on consideration of relevant TCR proposals and knowledge gaps. 
  3. Contribute to the development of call-specific information including detailed background to the call, scope, aims and objectives and desired outcomes.
  4. Perform other duties as directed by the NHMRC’s Chief Executive Officer.

Further Information

NHMRC has an online pathway for community and professional groups to propose ideas for health research topics, which NHMRC may develop into a Targeted Call for Research (TCR) and invite grant applications. 

NHMRC has received proposals for a TCR into lyme-like or tick borne disease:

Applications for Funding under the TCR

Any applications for funding in response to the TCR will be assessed by peer review, with a panel established at the time for that purpose.  The process is underpinned by the NHMRC Principles of Peer Review, the NHMRC Guide to Peer Review (2017 version on the following webpage) and any Scheme Specific Peer Review Guidelines.

Anticipated timeline

2017
  • Advisory Committee established
  • Advisory Committee deliberates and considers information available on the topic
2018
  • Advisory Committee completes work and formulates research question
  • Advisory Committee provides advice to NHMRC’s CEO
  • NHMRC finalises TCR call-specific documentation
  • TCR opens
  • Peer review panel assess applications
  •  NHMRC considers Peer Review Panel recommendations and makes recommendation to Minister for Health
  • Announcement of grants and funding commencing

Contact details

Queries about the work of the Advisory Committee should be directed to targeted.research@nhmrc.gov.au.