The objectives of the Medical Research Future Fund (MRFF) – 2022 Multiple Sclerosis Research grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

• Stream 1: promote Australian involvement in international collaborative investigator-initiated clinical trials testing the effectiveness of vaccines for prevention of latent Epstein-Barr virus infection through the establishment and coordination of clinical trials site/s in Australia

• Stream 2: clinical trials to accelerate the development or repurposing of therapeutic candidates (including antivirals) to treat Epstein-Barr virus for the purpose of preventing or treating conditions such as multiple sclerosis

• Stream 3: characterise how immune responses to viral infections trigger autoimmune diseases including multiple sclerosis in some individuals to generate knowledge that supports risk stratification so identified individuals can employ strategies to reduce their chance of developing autoimmune disease

• Stream 4: develop, implement and/or validate approaches for early intervention in individuals recovering from viral infections that aim to reduce the risk and/or severity of the long-term autoimmune consequences, including multiple sclerosis.

The intended outcome of the research funded by this grant opportunity is outlined in Section 1.3 of the grant guidelines.

For this grant opportunity, up to $18.0 million of funding is available over 4 years from 2022-23 for the four Streams of research as outlined in section 1.3.

Applicants to this grant opportunity must propose research that addresses one of the four Streams of research. An application may only be submitted to one of the above four Streams only. Applicants must specify the Stream to which they are applying in their application.

There will be two separate application forms in Sapphire to select from, one for Stream 1-2 and one for Stream 3-4.

This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health. 

Further information on the MRFF is available from the Department of Health’s MRFF website.

Outcomes of funding rounds